Inhibin B plasma concentrations in infertile patients with DAZ gene deletions treated with FSH

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Suppression of the high endogenous levels of plasma FSH in infertile men are associated with improved Sertoli cell function as reflected by elevated levels of plasma inhibin B.

BACKGROUND In vitro continuous stimulation of Sertoli cells with FSH leads to a desensitization of these cells to FSH action. To evaluate the presence of a desensitization of FSH receptor on Sertoli cells in vivo, we performed a controlled clinical study in 97 men affected by severe oligozoospermia. METHODS On the basis of FSH and inhibin B plasma concentrations, these subjects were divided i...

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The aim of this study was to investigate inhibin B and follicle stimulating hormone (FSH) secretion in a large group of oligozoospermic subjects affected by different degrees of testicular damage, before and after FSH treatment. A total of 135 oligozoospermic subjects (sperm count < 20 x 10(6)/ml) were evaluated for seminal parameters and FSH, luteinizing hormone (LH), testosterone and inhibin ...

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ژورنال

عنوان ژورنال: European Journal of Endocrinology

سال: 2002

ISSN: 0804-4643,1479-683X

DOI: 10.1530/eje.0.1460801